Extended-Interval Gentamicin Administration in Malnourished Children
نویسندگان
چکیده
منابع مشابه
Extended-interval aminoglycoside administration for children: a meta-analysis.
BACKGROUND There has been a long-standing debate regarding whether aminoglycosides should be administered on a multiple daily dosing (MDD) or once-daily dosing (ODD) schedule. Several unique characteristics of the aminoglycosides make ODD an attractive and possibly superior alternative to MDD. These include concentration-dependent bactericidal activity; postantibiotic effect, which allows conti...
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Various studies have reported the effect of severe malnutrition on electrolyte levels and electrocardiographic parameters. However, only a few have reported these findings in mild and moderate grades of malnutrition in children. Therefore, the objective of this study was to assess the effect of malnutrition (mainly mild and moderate grades) on corrected QT interval (QTc) and QT dispersion (QTcd...
متن کاملPharmacokinetic basis for the use of extended interval dosage regimens of gentamicin in neonates.
OBJECTIVES To analyse the pharmacokinetic basis for the use of extended-interval dosage regimens of gentamicin in neonates using population pharmacokinetics. PATIENTS AND METHODS The population pharmacokinetics of gentamicin was studied retrospectively in a population of 113 neonates divided into two groups: one for computing the population model (n=97) and another for validation (n=36). A on...
متن کاملExtended-interval Dosing of Gentamicin for Treatment of Neonatal Sepsis in Developed and Developing Countries
Serious bacterial infections are the single most important cause of neonatal mortality in developing countries. Case-fatality rates for neonatal sepsis in developing countries are high, partly because of inadequate administration of necessary antibiotics. For the treatment of neonatal sepsis in resource-poor, high-mortality settings in developing countries where most neonatal deaths occur, simp...
متن کاملLymphocyte transformation in malnourished children.
Selimeyer, E., Bhettay, E., Truswell, A. S., Meyers, 0. L., and Hansen, J. D. L. (1972). Archives of Disease in Childhood, 47, 429. Lymphocyte transformation in malnourished children. In vitro lymphocyte stimulation with phytohaemagglutinin gave subnormal transformation values in children with proteincalorie malnutrition. It is suggested that impaired cell-mediated immunity may be one important...
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ژورنال
عنوان ژورنال: Journal of Tropical Pediatrics
سال: 2005
ISSN: 1465-3664,0142-6338
DOI: 10.1093/tropej/fmi085